Neofibularia nolitangere, commonly known as the touch-me-not sponge, is a species of sea sponge in the family Biemnidae. It is found in shallow waters in the Western Atlantic Ocean and the Caribbean Sea.

Description Neofibularia nolitangere is a massive sponge often growing to about 30 centimetres (12 in) wide and 30 centimetres tall but sometimes reaching 1 metre (3 ft 3 in) in width. It has a central cavity or atrium with thick walls. It takes various forms in different areas of the Caribbean. In the Bahamas it usually occurs as a number of rounded lobes with a cup-shaped depression or cloaca on the apex of each. In these are several openings called osculi that slope diagonally to join the atrium and out of which water is propelled. Sometimes the sponge is encrusting, forming a shallow layer of tissue growing across the substrate. In other locations it grows as several concentric mounds with smaller cloacal openings or as large vase-type structures, single or in groups, sometimes fused together laterally. The general colour is deep brown or dark red.