Sepia hedleyi, or Hedley's cuttlefish, is a species of cuttlefish in the family Sepiidae, endemic to subtropical and temperate waters off Australia.

Description Sepia hedleyi is a relatively small species of cuttlefish with a mantle length of 83 mm in males and 102 mm in females. It is beige in colour lacking any markings on the arms. There are longitudinal rows of up to 6 ridge-like bumps forming ridges along each side, next to the base of each fin which vary in colour from orange to pink. The tentacular club is crescent-shaped and has a flattened surface which bears 9 to 12 suckers in transverse rows. The fins are widest in their posterior third, rounded at their posterior ends where there is a narrow separation between the fins. The cuttlebone is oblong.

Distribution Sepia hedleyi is endemic to the waters off Australia. Its range extends from the Great Barrier Reef off Queensland around the eastern, southern, and western coasts of Australia to just to the south west of Shark Bay in Western Australia, including Tasmania.

Habitat and ecology Sepia hedleyi occurs from shallow water to the continental slope, with the maximum depth recorded being 1092 m and the minimum 47 m.